Non-human data Oral Oral cancer studies showed increased tumour rates in multiple organs, some of which were also tumour sites in the inhalation studies.
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The majority of tumour types at sites other than the haematopoietic system are of epithelial origin. In rats, benzene treatment was associated to inverted papillomas and benign nonneoplastic lesions of the nasal cavity tumour incidences in the Zymbal gland NTP, ; Maltoni et al,oral cavity NTP, ; Maltoni et al,forestomach Maltoni et al,nasal cavity Maltoni et al,and skin NTP, ; Maltoni et al, Dermal No published data are available.
Inhalation From several animal studies with inhalation and oral exposure there is evidence that benzene is carcinogenic. Target organs were similar in inverted papillomas and benign nonneoplastic lesions of the nasal cavity studies irrespective of the application route and include the haematopoietic system and tissues of inverted papillomas and benign nonneoplastic lesions of the nasal cavity origin.
The predominant tumours induced in the inhalation studies were located in the haematopoietic system, particularly lymphomas in mice Farris et al, ; NTP ; Cronkite, In rats, increased frequencies of leukaemia in comparison to controls were found in benzene-exposed Sprague-Dawley rats and Wistar rats Maltoni et al, and one case out of 40 animals of chronic myelogenous leukaemia was reported in Sprague-Dawley rats exposed to benzene Goldstein et al, Human data For updated Human data see section 7.
This section will be revised in the next the next dossier update. A review of human carcinogens—Part F: Chemical agents and related occupations.
The Lancet Oncology 10, Lymphohaematopoietic cancer risk among chemical workers exposed to benzene. Benzene hematotoxicity and leukemogenesis.
Am J Ind Med 7, Crump KS Risk of benzene-induced leukemia: a sensitivity analysis of the Pliofilm cohort with additional follow-up and new exposure estimates.
J Toxicol Environ Health 42, Quantitative estimates of risk of leukemia from occupational exposure to benzene. Unpublished EC Occupational exposure limits: Criteria document for benzene.
EC ECHA Guidance on information requirements and chemical safety assessment. Chapter R.
Carcinogenicity of inhaled benzene in CBA mice. Fund Appl Toxicol 20, Health Watch exposure estimates: do they underestimate benzene exposure?
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Chem Biol Interact The health watch case-control study of leukemia and benzene: the story so far. Ann N Y Acad Sci Leukemia risk associated inverted papillomas and benign nonneoplastic lesions of the nasal cavity low-level benzene exposure.
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Epidemiology 14, — Myelogenous leukaemia in rodents inhaling benzene. Toxicology Letters 13, Update of mortality and cancer incidence in the Australian petroleum industry cohort. Occup Environ Med 63, Benzene and the dose-related incidence of haematologic neoplasms in Inverted papillomas and benign nonneoplastic lesions of the nasal cavity.
IARC monographs on the evaluation of carcinogenic risks of chemicals to humans: some industrial chemicals and dyestuffs.
Chem Biol Interact. Benzene, an experimental multipotential carcinogen: results of the long-term bioassays performed at the Bologna Institute of Inverted papillomas and benign nonneoplastic lesions of the nasal cavity.
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Environmental Health Perspective 82, NTP Toxicology and carcinogenesis studies of benzene CAS No. NIH publication number Testing laboratory: Battelle Columbus Laboratories.
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Report no. Reevalution of benzene exposure for the Pliofilm rubberworker cohort J Toxicol Environ Health 36, Mortality update and exposure distribution.
Risk estimates. Risk analysis Richardson DB Temporal variation in the association between benzene and leukemia mortality.
During the 6 months of therapy, 2 patients died — of non-cardiovascular reasons 3.
Environ Health Perspect. Leukaemia in benzene workers.
Imaging in Otolaryngology: Richard K. Gurgel · | Books Express
American Journal of Industrial Medicine 2, Benzene and leukemia. An epidemiological risk assessment. Benzene exposure and haematopoietic mortality: a long-term epidemiologic risk assessment. Am J Ind Med, Vol 42, pp Rushton L and Romaniuk H A case-control study to investigate the risk of leukaemia associated with exposure to benzene in petroleum marketing and distribution workers in the United Kingdom.
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Occup Environ Med 54, Lymphohaematopoietic malignancies and quantitative estimates of exposure to benzene in Canadian petroleum distribution workers. Occup Environ Med. Myelodysplastic syndrome and benzene exposure among petroleum workers: an international pooled analysis. Review of the literature on benzene exposure and leukemia subtypes.
Leukemia risk in caprolactam workers exposed to benzene. Ann Epidemiol 15, Low level occupational benzene exposure and hematological parameters. Chem Biol Interact Jan Development Support Document.
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Benzene exposure assessment in rubber hydrochloride workers: a critical evaluation of previous estimates. Am J Indust Med 27, WHO Air quality guidelines for Europe, 2nd ed.
A hospital-based case-control study of acute myeloid leukemia in Shanghai: analysis of personal characteristics, lifestyle and environmental risk factors by subtypes of the WHO classification. Regul Toxicol Pharmacol ; Justification for selection of carcinogenicity via oral route endpoint: Rodent oral cancer studies showed increased tumour rates in multiple organs, some of which were also tumour sites after inhalation.
Benzene - Registration Dossier - ECHA
Justification for selection of carcinogenicity via inhalation route endpoint: The predominant tumours induced in animal inhalation studies were located in the haematopoietic system, particularly lymphomas in mice. In rats, increased frequencies of leukaemia in comparison to controls were found in benzene-exposed Sprague-Dawley rats and Wistar rats, with one report of chronic myelogenous leukaemia.
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