Hepatocellular cancer statistics


Hepatocellular cancer statistics study was undertaken to evaluate the impact of type II diabetes on patients with hepatocellular carcinoma HCC. Material and methods. This is an observational study conducted in the Department of Oncology, Clinical Emergency County Hospital of Constanţa, for a period of four hepatocellular cancer statistics, from to A total of patients with HCC were analyzed.

hepatocellular cancer statistics

The patients were divided in two groups, with and without type II diabetes. In this study, there were included patients with hepatocellular carcinoma.

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Among all patients with HCC, 94 Of the patients with hepatocellular carcinoma, type II diabetes was found in 37 patients There is no difference between groups in relation to hepatocellular cancer statistics.

The average age in the group of HCC was 70 years, compared to the group hepatocellular cancer hepatocellular cancer statistics diabetic patients in which the mean age was of Hepatocellular carcinoma is a common cancer, with increased incidence in our region, hepatitis C and B being shown to be the most frequent causative agent.

Type 2 diabetes was present in The average age at diagnosis of HCC within the group of diabetic hepatocellular cancer statistics was significantly lower.

IMMUNOTHERAPY IN ADVANCED HEPATOCELLULAR CANCER

Mean survival was higher in non-diabetic patients and one-year mortality was significant higher in diabetic patients, concluding that diabetes may affect the long-term survival and can worsen the prognosis in these patients. Studiul a fost făcut pentru a evalua impactul diabetului de tip II la pacienții diagnosticați cu carcinom hepatocelular HCC.

Current treatment for advanced HCC includes mainly sorafenib and more recently approved regorafenib and nivolumab, as chemotherapy has shown little benefit. However, the modest benefit and the low response rate from systemic treatments suggest an increased need for new strategies. Recent scientific advances indicate a potential benefit from immunotherapy in hepatocellular carcinoma, due to its immunogenicity.

Materiale și metode. Acesta este un studiu observațional desfățurat în Departamentul de Oncologie a Spitalului Județean de Urgență Constanța, cu o durată de patru ani, din până în Au fost analizați în studiu de pacienți cu HCC.

Pacienții au fost împărțiți în două grupuri, cu și fără diabet de tip II.

Nu este nici o diferență între grupe în relație cu sexul pacienților. Vârsta medie a grupului fără diabet a fost de 70 de ani, iar la cei cu diabet hepatocellular cancer statistics de ani, cu o diferență semnificativă hepatocellular cancer statistics. Carcinomul hepatocelular este un cancer frecvent, cu incidență crescută în regiunea noastră, cel mai întâlnit agent cauzal  fiind infecția cu virus hepatic B și C. Vârsta medie la diagnosticul HCC a fost semnificativ mai mică.

The impact of type II diabetes on prognosis of patients with hepatocellular carcinoma

Supraviețuirea medie a fost mai mare la pacienții non-diabetici și mortalitatea la un an a fost semnificativ mai mare la pacienții diabetici, hepatocellular cancer statistics că diabetul poate afecta supraviețuirea pe termen lung și că reprezintă un factor de  prognostic negativ la acești pacienți.

Throughout the world, there are diagnosed each year approximatelynew cases of HCC. hepatocellular cancer statistics

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The most common and known risk factor are viral infection, hepatitis virus B or C, toxic factors - alcohol and aflatoxin, immune diseases like primary biliary cirrhosis, plus, in recent years, metabolic risk factors like diabetes and non-alcoholic hepatic steatosis 2,3.

A possible explanation for the association of diabetes with hepatocellular hpv und impfung is that diabetes is often part of the metabolic syndrome characterized by clinical and biochemical changes that include alterations in glucose metabolism and insulin, hepatocellular cancer statistics hyperglycemia and hyperinsulinemia, dyslipidemia and hypertension.

Metabolic disorders associated with metabolic syndrome can cause diabetes and furthermore contribute to the development of Hepatocellular cancer statistics non-alchoolic fatty liver disease and its most severe form, non-alcoholic steatohepatitis, so HCC can result from liver cirrhosis caused by NAFLD 4,5,6. Type II diabetes has an increased incidence worldwide.

Impactul diabetului de tip 2 asupra prognosticului pacienților cu carcinom hepatocelular

Epidemiologically, the relationship between HCV infection and diabetes is known, diabetes being reported to increase the risk of hepatocellular carcinoma in patients with chronic hepatitic C and also contributes to the excess mortality in this patients 7,8. Management of hepatocellular carcinoma is influenced by tumor status, liver function and by comorbidities, and diabetes is one of them 9, Material and methods This is an observational study conducted in the Department of Oncology, Clinical Emergency County Hospital of Constanţa, for a period of four years, from to One hundred and sixty-five patients diagnosed hepatocellular cancer statistics hepatocellular carcinoma were included in this study.

Patients were divided in two groups regarding the presence or absence of type II diabetes. Demographic profile, clinical features, etiology, tumor size, and presence of portal hepatocellular cancer statistics thrombosis were compared between groups.

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Data were evaluated using the statistical program SPSS Qualitative data included descriptive statistics, continuous variables are expressed as Mean and Standard Deviation, and T test was used to compare the two groups. Results In this study, there were included patients with hepatocellular hepatocellular cancer statistics.

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Demographic data are shown in Table 1. Mean age hepatocellular cancer statistics Cirrhosis was present in 94 patients and absent in Among patients with hepatic cirrhosis, the higher percentage was class Child-Pugh B: 39 In table 2, there are shown the clinical features at the time of diagnosis of hepatocellular carcinoma with or without type II hepatocellular cancer statistics. Regarding liver cirrhosis, in the non-diabetic group it was present in a higher percentage compared with the group hepatocellular cancer statistics diabetic patients, 78 cases Portal vein thrombosis is present in the group of non-diabetic patients in a percentage of Conclusions Hepatocellular carcinoma is a common cancer, with an increased incidence in our region, hepatitis C and B being shown to be the most frequent causative agent.

Type II diabetes was present in Cancer of the liver.

hepatocellular cancer statistics

Cancer: principles and practice of oncology. Diabetes increases the risk of hepatocellular carcinoma in the United States: a population based case control study.

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Gut, ; Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma. Gastroenterology, ; Cancer Lett, Further evidence for an association between non-insulindependent diabetes mellitus and chronic hepatitis C virus infection.

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Hepatology, ; 4 : Rathmann W, Giani G. Global prevalence of diabetes: estimates for the year and projections for Hepatocellular cancer statistics Care, ; 5 : Nasir Khokhar.

Association of chronic hepatitis C virus infection and diabetes mellitus.

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Pak J Med Res, ; 41 4 : Excess risk of primary liver cancer in patients with diabetes mellitus. J Natl Cancer Inst, ; 20 : Impact of diabetes mellitus on the prognosis of patients with hepatocellular carcinoma. Cancer, ; 5 : Effect of alcohol, cigarette smoking, and diabetes on occurrence of hepatocellular carcinoma in patients with transfusion-acquired hepatitis C virus infection who develop cirrhosis.

Eur J Gastroenterol Hepatol, ;

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