Colorectal cancer pathways


Although they seem to lack a clear connection, epidemiologic analysis found a significant association.

colorectal cancer pathways

This led to further evaluation and identification of molecular pathways that stand at the basis of these findings. One of them is chronic inflammation, a state associated with obesity and colorectal cancer. Adipose tissue from obese individuals suffers a pathogenic switch responsible colorectal cancer pathways higher inflammatory capacity.

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This modulates the interplay between inflammation and colorectal cancer cells. Through growth factors and cytokines, adipose tissue creates a favorable microenvironment for tumor development.

Although the causes of this disease are not entirely understood, it is known that several factors influence its occurrence. Risk factors for colorectal cancer include age, family history of colon polyps, inflammatory bowel disease and hereditary syndromes, smoking, obesity, sedentarism, alcohol consumption. Evidence is mounting that detecting this risk factors is a eficient way of selecting persons at high risk for colon cancer, that should undergo the screening mesures.

Our focus is on the ghrelin-growth hormone secretagogue receptor axis which promotes inflammation and has mitogenic and antiapoptotic capacity on colorectal cancer pathways cells, acting through various mechanisms including via TNF-α which promotes tumor cell proliferation, growth and metastasis and IL-6, a molecule associated with tumor size and stage in colorectal cancer patients.

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Ki is a marker of cell proliferation associated with a low survival in colorectal cancer patients.

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